Virus Production

HALIX offers GMP viral production of vaccines, viral vectors and oncolytic viruses in our BSL2 cleanroom production plant

Viral Vectors, Vaccines and Therapeutics

Viruses are broadly used in modern medicine with prophylactic vaccines as the best proven technology. Most recently, viruses have been used as gene therapy vectors to cure patients with genetic deficiencies or mutations. This kind of virus can also be used to train our immune system to recognize and clear up cancerous cells using for example CAR-T technology. In a more direct approach to treating cancer, oncolytic viruses have been modified in such a way that they selectively infect and eliminate tumor cells, without affecting healthy cells.

Virus Production at HALIX

Viruses are typically produced using Eukaryote cells as a substrate. The industry workhorse for viral production is the interferon negative VERO cell line. Naturally, HALIX is also experienced in handling a broad range of other cell lines from mammalian and insect origin. HALIX can grow these cells in flasks, roller bottles and bioreactors, depending on the scale required. After infection and subsequent harvest, HALIX can purify the virus to form the drug substance.

Several chromatography, centrifugation and filtration steps can be needed to remove impurities without harming the product. Our experts can help you optimize your DSP strategy to ensure maximum product yield and quality. HALIX can perform formulation as well as fill and finish, which is the next step in the production process. To finalize the process HALIX can label and pack the completed drug product vials, ready to go to the clinic to treat patients after release by our QP.

HALIX Full Service Offering

HALIX has produced viral vectors, prophylactic vaccines and oncolytic viruses in our BSL2 cleanroom facilities. We have dedicated class C cleanrooms for cell culture, for upstream processing and for downstream processing, and in our Class B cleanrooms we can fill and finish drug product into its final container. Our processes run completely on single use technology, minimizing risk and ensuring scale up from lab to industrial scale goes smoothly.

Our experts can help you fine tune your processes and optimize your outcome. Outsourcing to HALIX provides you a cost-effective way to produce your viral vaccines in a safe and GMP compliant way.

Contact us to learn how we can support your needs in GMP virus production.